Fresh analysis indicates that individuals who stop using new weight-loss injections like semaglutide or tirzepatide can put back on reduced body mass far faster than those who halt traditional diet and exercise plans.
Research printed in a prominent health publication points out that while overweight individuals can lose substantial amounts of their total mass while on the medication, the mass comes back at an estimated rate of nearly a kilo each month after stopping.
"Individuals purchasing these drugs should be aware of the risk of fast rebound weight gain when the medication concludes," cautioned expert Dr. Susan Jebb.
Such speed of recovery implies a return to starting mass in about a year and a half.
Weighing Approaches
The analysis, which examined 37 of trials involving thousands of patients, compared the effects of the injectable medications with other pills.
The team emphasize that people who lose weight through lifestyle changes alone typically see a more gradual weight regain—perhaps 0.1 kg a month—once they finish.
The Reason for the Quick Regain
Nutrition scientists believe the way of the injections accounts for the heightened regain.
The injections mimic a natural hormone called GLP-1, which moderates hunger.
"Long-term administration of the hormone levels far above than the body's typical production might result in the system to produce less of its endogenous hormone, and could diminish sensitivity to its effects," said Dr. Adam Collins, a dietetics specialist.
"Discontinuation of this hormone supplement results in appetite is no longer kept in check, making binge eating a significant risk."
A Chronic Issue?
The NHS advise the injections for people with weight-linked health risks, accompanied by prescribed lifestyle changes.
Professionals argue that, due to the significant potential of weight regain, the treatment is often long-term.
This opinion is echoed by drug manufacturers, who say that the findings "underscore the long-term nature of excess weight," comparing it to managing diseases like high blood pressure.
Patient Testimonies
Individuals who have come off the medication explain a sudden return of cravings.
"It felt as if a trigger activating and I was suddenly extremely hungry," recalled an individual.
This difficulty is worsened if individuals have not established permanent dietary or behavioural modifications during treatment.
Significant Adoption
Figures suggest that a significant number of adults in the UK have tried weight-loss jabs in the last 12 months, with desire continuing to grow.
- Adoption is higher among women than men.
- The middle-aged demographic shows the greatest level of interest.
- A large proportion access the medications through private prescriptions rather than the NHS.
Ultimately, experts stress that while these medications are potent agents for weight loss, they are not a standalone solution and lasting health benefits hinges on ongoing behavioural support.